The first real uses of Newtonian physics are due to Newton himself. In his principia, he
Derived Kepler's laws from the law of gravitation,
Determined the first correct approximation for the shape of the Earth, after the sphere.
Explained the tides.
Partially explained the inequalities of the Moon motion.
Explained the motion of comets which enabled Halley to predict the return of the Halley comet.
These are his most famous achievements, but there were plenty of others. Further development of this occupied many mathematicians for the rest of 18th century, and more. All this had very substantial applications to real life, first of all to navigation.