In the history of science and technology, there are some cases, when scientists don'tdid not believe into something, which appear real that later turned out to be real.
For example, Bill Gates was saying 640K is sufficient to any computer :)
WasDid such thing happen in the history of nuclear weapon? Did someone famous not believed into itbelieve nuclear weapons were possible?
UPDATE
May beMaybe some problems were regarded as unsolveableunsolvable initially, for example obtaining pure enough fuel or handling undercriticallundercritical masses?
UPDATE 2
Urban legends also ok. For example, if it was popular opinion, that A said something impossible.
UPDATE 3
Let's try to narrow the time. Let it be before the discovery of neutron and fission (1932). Wasn't it possible to understand, that that the nucleus contain a lot of binding energy, but withoutnot knowing about fission to doubt, that it can be extracted?