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The sentence is Latin for nature doesn't make jumps. It refers to the fact that, in most physical processes, quantities vary continuously.

The principle was used by Leibniz, Kant and Darwin among others.

The best source I found for this sentence, tracking back from Wikipedia, is this website (in german). There it is stated that the sentence appeared already in Discours véritable de la vie... du géant Theutobocus (1613), where one finds the sentence in its singular (saltum) version:

Natura in operationibus suis non facit saltum.

Is this the first occurence of this phrase? It's possible that a single author cannot be found, in any case when did the phrase first appear? Should the phrase be attributed to Theutobocus?

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    $\begingroup$ The text Reproducibility: Principles, Problems, Practices, and Prospects claims that the first explicit use of "Natura non facit saltus" is due to Linne 1751 (Chapter III, par 77, 27), although this is much later than your reference to Theutobocus (1613). $\endgroup$
    – nwr
    Commented Apr 13, 2020 at 3:17
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    $\begingroup$ @Nick thanks, that is weird as that put it even after Leibniz who died in 1716 and seems credited with quoting the principle in various occasion. $\endgroup$
    – lcv
    Commented Apr 13, 2020 at 3:35
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    $\begingroup$ Perhaps the author's qualification of "explicit use" refers to the exact phrasing. He does comment that the principle is ancient. $\endgroup$
    – nwr
    Commented Apr 13, 2020 at 3:50
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    $\begingroup$ Regarding the Linné attribution, the wiki article states "The Latin translation comes from Linnaeus' Philosophia Botanica." I probably should have read that first. $\endgroup$
    – nwr
    Commented Apr 13, 2020 at 4:03
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    $\begingroup$ Guess he never saw a major earthquake :-) . And of course in reality it all depends on your time scale. See "punctuated equilibrium" and "tipping point" for more recent views of Nature. $\endgroup$ Commented Apr 13, 2020 at 13:32

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The Latin quip was derived from Aristotle's History of Animals, where it is rather specific to the context of the "scale of life". Hence Linnaeus's and Darwin's references are more on point than more sweeping post-Aristotelian generalizations about "most physical processes", some quite remarkable in how obviously false they are. It should also be said that Darwin's use had a very specific target, Georges Cuvier and his paleontological catastrophism (which was already replaced by Lyell's gradualism, Darwin's inspiration) extended to biology. Here is Aristotle:

"Nature proceeds little by little from things lifeless to animal life in such a way that it is impossible to determine the exact line of demarcation, nor on which side thereof an intermediate form should lie. Thus, next after lifeless things in the upward scale comes the plant, and of plants one will differ from another as to its amount of apparent vitality; and, in a word, the whole genus of plants, whilst it is devoid of life as compared with an animal, is endowed with life as compared with other corporeal entities. Indeed, as we just remarked, there is observed in plants a continuous scale of ascent towards the animal."

Already Pliny the Elder in Naturalis Historia extended Aristotle's scale to scala naturae, and this is the "ladder" Kant refers to. Plotinus and Christian authors took it all the way to the Heaven as a "great chain of being" much earlier, see Archibald, Aristotle’s Ladder, Darwin’s Tree.

As for the quip, "Theutobocus" is not the author name, the reference is to Discours véritable de la vie, mort et des os du géant Theutobocus by a rather obscure Jacques Tissot (Lyon, 1613). The "bones of giant Theutobocus" apparently referred to bones of a mastodon presented as those of a human giant in a hoax. That a French work inserts a Latin quip, calling it an "axiom" no less, suggests that it was already in circulation by then. Classical and Foreign Quotations, p. 209 confirms it:

"Tissot is quoting an old and well-established principle of physics. "Operatur natura", he says, "quantum et quandim potest, sans neant moins faire aucun sault ab extremis ad extrema. Natura enim in operationibus suis non facit saltum". His contemporary, Sir E. Coke, applies it to law:"Natura non facit saltus, ita nec lex". Coke upon Littleton, pp 238b, 239."

And then it goes to Leibniz and Linnaeus. Wicksteed in Studies in Theology, p. 30 adds the following:

"I have not been able to trace it further back in the form of an aphorism, but the principle is taken for granted by Dante as holding good in the physical universe, and is applied by him to the intellectual order."

A lengthy quote from Dante's Convivio, III.7 follows, where the "great chain of being" is on full display:

"And since in the intellectual order of the universe the ascent and descent are almost by continuous gradations from the lowest form to the highest and from the highest to the lowest, as we see in the order of beings capable of sensation; and since between the angelic nature, which is intellectual being, and the human nature there is no gradation but rather the one is, as it were, continuous with the other by the order of gradation; and since between the human soul and the most perfect soul of the brute animals there is also no intermediary gradation, so it is that we see many men so vile and in such a state of baseness that they seem to be almost nothing but beasts. Consequently it must be stated and firmly believed that there are some so noble and so lofty in nature that they are almost nothing but angels, for otherwise the human species would not be continuous in both directions, which is impossible."

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